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Review
. 1992 May;13(5):157-60.
doi: 10.1016/0167-5699(92)90118-Q.

Nitric oxide: a pathogenetic factor in autoimmunity

H Kolb  1 , V Kolb-Bachofen
Affiliations
Review

Nitric oxide: a pathogenetic factor in autoimmunity

H Kolb et al. Immunol Today. 1992 May.

Abstract

Nitric oxide (NO) has been identified recently as a multifunctional mediator, produced by, and acting on, most cells of the body. Besides its function as endothelium-derived relaxing factor, as a neurotransmitter and as an immune defence molecule, evidence is accumulating that NO participates in inflammatory- and autoimmune-mediated tissue destruction. Modulation of NO synthesis and action represents a new approach to the treatment of inflammatory and autoimmune conditions.

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