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. 1960 Apr 29;131(3409):1312.
doi: 10.1126/science.131.3409.1312.

Enzymatic O-methylation of N-acetylserotonin to melatonin

J AXELROD, H WEISSBACH

Enzymatic O-methylation of N-acetylserotonin to melatonin

J AXELROD et al. Science. .

Abstract

An enzyme, hydroxyindole-O-methyl transferase, that can transfer the methyl group of S-adenosylmethionine to the hydroxy group of N-acetylserotonin to form the hormone melatonin is described. This enzyme, which is highly localized in the pineal gland, also O-methylates serotonin.

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