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. 1992 Jul 31;186(2):1108-14.
doi: 10.1016/0006-291x(92)90861-e.

A plasminogen-related gene is expressed in cancer cells

L Weissbach  1 , B V Treadwell
Affiliations

A plasminogen-related gene is expressed in cancer cells

L Weissbach et al. Biochem Biophys Res Commun. .

Abstract

The breakdown of blood clots requires the fibrinolytic action of the serine proteinase plasmin, a two-chain polypeptide derived posttranslationally from its precursor zymogen, plasminogen. While investigating plasminogen gene expression in human extrahepatic tissues, a cDNA sequence was obtained which closely resembled the plasminogen cDNA, yet appeared to represent a distinct gene product. This sequence, which represents the transcript of the recently characterized plasminogen-related gene B, encodes a putative polypeptide of Mr 8800 and is expressed most prominently in malignant cancer cells.

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