Electrochemotherapy tumor treatment is improved by interleukin-2 stimulation of the host's defenses
Affiliations
- PMID: 1379837
Item in Clipboard
Electrochemotherapy tumor treatment is improved by interleukin-2 stimulation of the host's defenses
Eur Cytokine Netw.
1992 May-Jun.
Abstract
We have recently described a new antitumor treatment, electrochemotherapy (ECT), based on the large local potentiation of the effects of the chemotherapeutic agent bleomycin (BLM) by electric pulses (EP) delivered at the tumor site. We demonstrate here that the host's immune response participates in cure achievement. We obtain an increase of the rate of completely cured animals by injecting mice with interleukin-2 (IL-2).
Similar articles
-
Host's immune response in electrotherapy of murine tumors by direct current.Eur Cytokine Netw. 1997 Sep;8(3):275-9. Eur Cytokine Netw. 1997. PMID: 9346361
-
[Potentiation of the antitumoral effect of electrochemotherapy by immunotherapy with allogeneic cells producing interleukin 2].C R Acad Sci III. 1992;314(12):539-44. C R Acad Sci III. 1992. PMID: 1381659 French.
-
Systemic antitumor effects of electrochemotherapy combined with histoincompatible cells secreting interleukin-2.J Immunother Emphasis Tumor Immunol. 1995 Jan;17(1):30-8. doi: 10.1097/00002371-199501000-00004. J Immunother Emphasis Tumor Immunol. 1995. PMID: 7537154
-
[Antitumor electro-chemotherapy].Bull Cancer. 1994 Sep;81(9):740-8. Bull Cancer. 1994. PMID: 7535603 Review. French.
-
Electrochemotherapy: a new treatment of solid tumors.J Exp Clin Cancer Res. 2003 Dec;22(4 Suppl):145-8. J Exp Clin Cancer Res. 2003. PMID: 16767921 Review.
Cited by
-
The importance of electric field distribution for effective in vivo electroporation of tissues.Biophys J. 1998 May;74(5):2152-8. doi: 10.1016/S0006-3495(98)77924-X. Biophys J. 1998. PMID: 9591642 Free PMC article.
-
Electrochemotherapy on liver tumours in rabbits.Br J Cancer. 1998 Jun;77(12):2104-11. doi: 10.1038/bjc.1998.354. Br J Cancer. 1998. PMID: 9649121 Free PMC article.
-
The Effect of Millisecond Pulsed Electric Fields (msPEF) on Intracellular Drug Transport with Negatively Charged Large Nanocarriers Made of Solid Lipid Nanoparticles (SLN): In Vitro Study.J Membr Biol. 2016 Oct;249(5):645-661. doi: 10.1007/s00232-016-9906-1. Epub 2016 May 12. J Membr Biol. 2016. PMID: 27173678 Free PMC article.
-
Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy.Br J Cancer. 1998 Jun;77(12):2336-42. doi: 10.1038/bjc.1998.388. Br J Cancer. 1998. PMID: 9649155 Free PMC article. Clinical Trial.
-
Electrical Stimulation for Immune Modulation in Cancer Treatments.Front Bioeng Biotechnol. 2022 Jan 11;9:795300. doi: 10.3389/fbioe.2021.795300. eCollection 2021. Front Bioeng Biotechnol. 2022. PMID: 35087799 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources