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. 1959 Nov 1;110(5):827-44.
doi: 10.1084/jem.110.5.827.

Sequential cellular changes produced by types 5 and 7 adenoviruses in HeLa cells and in human amniotic cells; cytological studies aided by fluorescein-labelled antibody

G S BOYER, F W DENNY Jr, H S GINSBERG

Sequential cellular changes produced by types 5 and 7 adenoviruses in HeLa cells and in human amniotic cells; cytological studies aided by fluorescein-labelled antibody

G S BOYER et al. J Exp Med. .

Abstract

The sequential cytological changes which develop in tissue culture cells infected with adenovirus types 5 and 7 are described and compared with those produced by adenovirus types 1, 2, 3, and 4. The evidence that is presented indicates that types 1, 2, and 5 belong to one major subdivision of the adenovirus group and types 3, 4, and 7 to another. That the host cell nucleus is the principal site of adenovirus synthesis has been confirmed by fluorescent antibody studies. They have demonstrated the occurrence of type-specific adenovirus antigen in the characteristic intranuclear inclusions and other virus-induced structures reported to contain virus-like particles or shown by electronmicroscopy.

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References

    1. J Exp Med. 1950 Jan 1;91(1):1-13 - PubMed
    1. J Biophys Biochem Cytol. 1957 May 25;3(3):505-8 - PubMed
    1. J Exp Med. 1956 Sep 1;104(3):443-54 - PubMed
    1. Proc Soc Exp Biol Med. 1954 Aug-Sep;86(4):789-94 - PubMed
    1. Nature. 1955 Mar 19;175(4455):505-6 - PubMed