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Review
. 1992 Feb;24(1):33-9.
doi: 10.1007/BF00769528.

The cation-selective substate of the mitochondrial outer membrane pore: single-channel conductance and influence on intermembrane and peripheral kinases

R Benz  1 , D Brdiczka
Affiliations
Review

The cation-selective substate of the mitochondrial outer membrane pore: single-channel conductance and influence on intermembrane and peripheral kinases

R Benz et al. J Bioenerg Biomembr. 1992 Feb.

Abstract

The polyanion-induced substate of the outer mitochondrial membrane was studied in vivo and in vitro. Study of the substate in artificial bilayers showed that it is highly cation selective. The induction of the substate in intact mitochondria leads to a complete inhibition of the intermembrane kinases, such as creatine kinase and adenylate kinase, which were excluded from the external ATP pool. Peripheral kinases, such as hexokinase, were blocked when they utilized internal ATP. The results with intact mitochondria suggested the existence of two regions of the outer membrane containing channels of different states, which may be involved in the regulation of intermembrane and peripheral kinases.

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References

    1. Biochim Biophys Acta. 1979 Mar 8;551(2):238-47 - PubMed
    1. Annu Rev Physiol. 1985;47:707-25 - PubMed
    1. Biochim Biophys Acta. 1977 Nov 17;462(2):380-9 - PubMed
    1. Biochim Biophys Acta. 1983 Aug 24;733(1):102-10 - PubMed
    1. J Biochem. 1979 May;85(5):1151-6 - PubMed

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