Transmembrane signalling in T cells

Abstract

Transmembrane signalling to activate T cells to proliferate and differentiate is a complex multistep process. It is the focus of much current interest, mostly because a selective and well-controlled inhibition of the process will allow regulation, or at least modulation, of the immune response. Here, Sándor Damjanovich and colleagues review the contributions of Hungarian scientists to the understanding of signalling in lymphocytes in particular, and cell activation in general.