doi: 10.1016/0006-8993(92)91380-w.
Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia
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- PMID: 1380876
- DOI: 10.1016/0006-8993(92)91380-w
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Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia
Brain Res.
.
Abstract
We examined whether preconditioning with sublethal ischemia protects against neuronal damage following subsequent lethal ischemic insults. Forebrain ischemia for 3 min in Wistar rats increased heat shock protein-70 immunoreactivity in the hippocampal CA1 subfield but produced no neuronal damage. Preconditioning with 3 min of ischemia followed by 3 days of reperfusion protected against hippocampal CA1 neuronal damage following 6 and 8 min of ischemia but not damage after 10 min of ischemia. The result strongly suggests that stress response induced by sublethal ischemia protects against ischemic brain damage.
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