Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1959 Sep 1;110(3):481-94.
doi: 10.1084/jem.110.3.481.

The role of polymorphonuclear leukocytes in the initiation and cessation of the Arthus vasculitis

C G COCHRANE, W O WEIGLE, F J DIXON

The role of polymorphonuclear leukocytes in the initiation and cessation of the Arthus vasculitis

C G COCHRANE et al. J Exp Med. .

Abstract

The role of polymorphs in the Arthus type hypersensitivity vasculitis has been studied. Polymorphs were found to play an essential role in not only producing the inflammatory vasculitis, but also were instrumental in ridding the damaged vessel of the antigen, probably by means of proteolytic catabolism at the inflammatory site. A temporal relationship between the disappearance of antigen from the damaged vessels and a decrease in inflammatory reaction was found. The earliest localization of antigen and its associated rabbit globulin in the Arthus vasculitis was found to be beneath the endothelium of small vessels. Since submitting this article for publication, Sorkin and Boyden (J. Immunol., 1959, 82, 332) have reported the catabolism of antigen in the presence of antibody by mononuclear cells obtained from the peritoneal cavities of guinea pigs. Evidence was presented indicating that the antigen molecule was actually broken down by the mononuclear cells. Techniques similar to those reported here were used.

PubMed Disclaimer

References

    1. Proc Soc Exp Biol Med. 1953 Oct;84(1):165-7 - PubMed
    1. Br J Exp Pathol. 1955 Jun;36(3):268-82 - PubMed
    1. J Exp Med. 1958 Nov 1;108(5):591-604 - PubMed
    1. J Immunol. 1959 Apr;82(4):332-9 - PubMed
    1. J Immunol. 1959 Jun;82(6):516-9 - PubMed