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. 1959 Nov 27;130(3387):1478-9.
doi: 10.1126/science.130.3387.1478.

Induced synthesis of liver microsomal enzymes which metabolize foreign compounds

A H CONNEY, J R GILLETTE, J K INSCOE, E R TRAMS, H S POSNER

Induced synthesis of liver microsomal enzymes which metabolize foreign compounds

A H CONNEY et al. Science. .

Abstract

The administration of 3,4-benzpyrene to rats markedly increases the activities of certain liver microsomal enzymes which metabolize foreign compounds. Evidence based on studies of enzyme induction is presented which suggests the presence in liver microsomes of several enzymes which can catalyze the same type of reaction.

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