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. 1992 Aug 30;153(1-2):85-91.
doi: 10.1016/0022-1759(92)90309-h.

A monoclonal antibody recognising an epitope associated with pig interleukin-2 receptors

M Bailey  1 , K Stevens, P W Bland, C R Stokes
Affiliations

A monoclonal antibody recognising an epitope associated with pig interleukin-2 receptors

M Bailey et al. J Immunol Methods. .

Abstract

A monoclonal antibody is described which recognises an epitope associated with a receptor for interleukin-2 (IL-2) on pig lymphocytes. The monoclonal antibody inhibits high affinity binding of radiolabelled recombinant human IL-2 (rhIL-2) by pig lymphoblasts and also non-competitively inhibits both pig-TCGF and rhIL-2 maintained proliferation. By flow cytometry the antigen is apparently not present on freshly isolated blood lymphocytes but is detectable on small cells between 6 and 12 h after activation and on large cells by 24-h. These findings are comparable with those obtained using monoclonal antibodies recognising the 55 kDa alpha chain of the human and mouse IL-2 receptor (p55, TAC) expressed on activated cells in vivo and in vitro. However, the molecular weight of the porcine antigen is between 65 and 70 kDa.

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