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. 1960 Jul;7(4):747-52.
doi: 10.1083/jcb.7.4.747.

Further electron microscope studies of a mouse leukemia induced by cell-free filtrates

E DE HARVEN, C FRIEND

Further electron microscope studies of a mouse leukemia induced by cell-free filtrates

E DE HARVEN et al. J Biophys Biochem Cytol. 1960 Jul.

Abstract

Further electron microscope observations of tissues from Swiss and DBA/2 mice with leukemia transmissible by cell-free filtrates to the adult animals are presented. The cytological characteristics of the leukemic cells, the fine structure of the viruses, and the virus host-cell relationships have been examined. The leukemia virus has an external diameter averaging 870 A, and appears to be formed at the level of cell membranes by a budding process. The viruses are observed most frequently in intercellular spaces, but are also often found within cytoplasmic vacuoles of megakaryocytes. Lead hydroxide staining was applied to the study of the leukemic material. The viruses have been found to have a considerable affinity for this lead salt, only comparable in intensity to the affinity shown by RNP granules for the same chemical.

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References

    1. J Ultrastruct Res. 1958 Aug;1(4):309-36 - PubMed
    1. J Biophys Biochem Cytol. 1958 Mar 25;4(2):151-6 - PubMed
    1. J Biophys Biochem Cytol. 1958 Nov 25;4(6):727-30 - PubMed
    1. Cancer Res. 1958 Jun;18(5):491-509 - PubMed
    1. C R Hebd Seances Acad Sci. 1958 Nov 17;247(20):1802-5 - PubMed