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. 1992 Sep;66(3):439-43.
doi: 10.1038/bjc.1992.293.

12-O-tetradecanoylphorbol 13-acetate induced differentiation in human lung squamous carcinoma cells

G J Rabiasz  1 , S P Langdon, L Anderson, A A Ritchie, W R Miller, J F Smyth
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Free PMC article

12-O-tetradecanoylphorbol 13-acetate induced differentiation in human lung squamous carcinoma cells

G J Rabiasz et al. Br J Cancer. 1992 Sep.
Free PMC article

Abstract

Three human lung squamous carcinoma cell lines (NX002, CX140 and CX143) demonstrate features of squamous differentiation including involucrin synthesis and competence to form cornified envelopes. 12-O-Tetradecanoylphorbol 13-acetate inhibits growth of these cell lines and this growth inhibition is associated with enhanced differentiation.

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