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. 1992 Aug;106(4):764-5.
doi: 10.1111/j.1476-5381.1992.tb14409.x.

Ca2+ release from isolated sarcoplasmic reticulum of guinea-pig psoas muscle induced by K(+)-channel blockers

Y Ishida  1 , H Honda, T X Watanabe
Affiliations

Ca2+ release from isolated sarcoplasmic reticulum of guinea-pig psoas muscle induced by K(+)-channel blockers

Y Ishida et al. Br J Pharmacol. 1992 Aug.

Abstract

A Ca(2+)-sensitive electrode was used to measure the Ca2+ concentration of the medium containing the heavy fraction of the fragmented sarcoplasmic reticulum (SR) prepared from guinea-pig psoas muscle. Among K(+)-channel blockers tested, 4-aminopyridine (4-AP), tetraethylammonium (TEA) and charybdotoxin elicited Ca2+ release from the SR, but apamin and glibenclamide did not. These results suggest that a reduction of SR K+ conductance leads to Ca2+ release from the SR.

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References

    1. J Biol Chem. 1983 Aug 25;258(16):9662-8 - PubMed
    1. Biochem Biophys Res Commun. 1990 Jul 31;170(2):684-90 - PubMed
    1. Pflugers Arch. 1991 Feb;417(6):651-3 - PubMed
    1. J Pharmacol Exp Ther. 1988 Aug;246(2):667-73 - PubMed
    1. Nature. 1985 Jan 24-30;313(6000):316-8 - PubMed