doi: 10.1111/j.1476-5381.1992.tb14410.x.
The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia
Affiliations
- PMID: 1382786
- PMCID: PMC1907643
- DOI: 10.1111/j.1476-5381.1992.tb14410.x
Item in Clipboard
The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia
Br J Pharmacol.
1992 Aug.
Abstract
Recent data showed that glutamate toxicity in primary cortical cultures is mediated by nitric oxide. In order to investigate the effect of inhibition of NO synthase on focal cerebral ischaemia in rats, we studied the histological consequences of a middle cerebral artery (MCA) occlusion after post-operative treatment with NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase. We found a significant reduction of cortical (-43%) and striatal (-25%) necrotic volumes induced by MCA occlusion, indicating that NO synthesis plays an important role in the neurotoxic cascade leading to neuronal damage after focal cerebral ischaemia in rats.
Similar articles
-
Anti-ischaemic efficacy of a nitric oxide synthase inhibitor and a N-methyl-D-aspartate receptor antagonist in models of transient and permanent focal cerebral ischaemia.Br J Pharmacol. 1994 Sep;113(1):247-53. doi: 10.1111/j.1476-5381.1994.tb16201.x. Br J Pharmacol. 1994. PMID: 7529111 Free PMC article.
-
Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia.J Neurochem. 1993 Aug;61(2):690-6. doi: 10.1111/j.1471-4159.1993.tb02174.x. J Neurochem. 1993. PMID: 7687658
-
L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat.Stroke. 1994 Feb;25(2):429-35. doi: 10.1161/01.str.25.2.429. Stroke. 1994. PMID: 7508154
-
The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia.Brain Pathol. 1994 Jan;4(1):49-57. doi: 10.1111/j.1750-3639.1994.tb00810.x. Brain Pathol. 1994. PMID: 7517769 Review.
-
Cytoprotective therapies in stroke.Curr Opin Neurol. 1995 Feb;8(1):15-23. doi: 10.1097/00019052-199502000-00004. Curr Opin Neurol. 1995. PMID: 7749511 Review.
Cited by
-
Nitric oxide synthesis, epileptic seizures and kindling.Psychopharmacology (Berl). 1995 May;119(1):115-23. doi: 10.1007/BF02246062. Psychopharmacology (Berl). 1995. PMID: 7675942
-
Oxidative Stress Induced Mitochondrial Failure and Vascular Hypoperfusion as a Key Initiator for the Development of Alzheimer Disease.Pharmaceuticals (Basel). 2010 Jan 19;3(1):158-187. doi: 10.3390/ph3010158. Pharmaceuticals (Basel). 2010. PMID: 27713247 Free PMC article. Review.
-
Lysine and arginine reduce the effects of cerebral ischemic insults and inhibit glutamate-induced neuronal activity in rats.Front Integr Neurosci. 2010 Jun 14;4:18. doi: 10.3389/fnint.2010.00018. eCollection 2010. Front Integr Neurosci. 2010. PMID: 20589237 Free PMC article.
-
Preconditioning with a novel metallopharmaceutical NO donor in anesthetized rats subjected to brain ischemia/reperfusion.Neurochem Res. 2012 Apr;37(4):749-58. doi: 10.1007/s11064-011-0669-x. Epub 2011 Dec 10. Neurochem Res. 2012. PMID: 22160748
-
Neural roles for heme oxygenase: contrasts to nitric oxide synthase.Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):10996-1002. doi: 10.1073/pnas.191351298. Proc Natl Acad Sci U S A. 2001. PMID: 11572959 Free PMC article. Review.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
