Comparative Study
doi: 10.1007/BF00506506.
The effect of 4-dimethylaminoazobenzene and azobenzene on the immune reaction of male Sprague-Dawley rats
- PMID: 138279
- DOI: 10.1007/BF00506506
Item in Clipboard
Comparative Study
The effect of 4-dimethylaminoazobenzene and azobenzene on the immune reaction of male Sprague-Dawley rats
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol.
.
Abstract
The carcinogenic substance 4-dimethylaminoazobenzene and the non-carcinogen azobenzene were administered orally once a day to male Sprague-Dawley rats over several weeks at an equimolar dosage of 5-10(-5) moles/kg. Their immunological properties were examined in four different tests. The two substances suppress the cellular immune reactions of the rats already during the first month of treatment. The degree of efficiency of the immunosuppressive property decrease with the degree of antigenicity of the test antigen. Even a two-month treatment of the animals with the two substances had no evident influence on antibody formation. Correlations between the immune response and the carcinogenic effect were not demonstrable.
Similar articles
-
Carcinogenic activity of analogues of p-dimethylaminoazobenzene. V. Effect of added methyl groups in the pyridine series.J Natl Cancer Inst. 1966 Sep;37(3):365-7. doi: 10.1093/jnci/37.3.365. J Natl Cancer Inst. 1966. PMID: 4288598 No abstract available.
-
[Antigenic rearrangement in the liver of mice and rats as a result of simultaneous effect of the carcinogens].Tsitologiia. 1977 Jul;19(7):781-5. Tsitologiia. 1977. PMID: 201056 Russian.
-
[Changes in tryptophan pyrrolase activity in the rat liver after a single injection of the hepatocarcinogen 4-dimethylaminoazobenzene and its noncarcinogenic analog].Tsitologiia. 1982 May;24(5):615-7. Tsitologiia. 1982. PMID: 6808731 Russian.
-
[Effect of some azo compounds on 1-leucine incorporation by the liver microsome system].C R Acad Hebd Seances Acad Sci D. 1965 May 3;260(18):4871-3. C R Acad Hebd Seances Acad Sci D. 1965. PMID: 4954064 French. No abstract available.
-
Methemoglobin--induced by carcinogenic aminoazo dyes in rats.Biochem Pharmacol. 1972 Aug 1;21(15):2147-50. doi: 10.1016/0006-2952(72)90170-0. Biochem Pharmacol. 1972. PMID: 4630321 No abstract available.
References
-
- Br J Cancer. 1974 Dec;30(6):512-23 - PubMed
-
- Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;81(3-4):211-5 - PubMed
-
- Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 May 3;86(1):89-94 - PubMed
-
- Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1972;77(3):189-93 - PubMed
-
- Recent Results Cancer Res. 1975;(52):76-87 - PubMed