Comparative Study
doi: 10.1099/0022-1317-73-9-2445.
Highly conserved epitope domain in major core protein p24 is structurally similar among human, simian and feline immunodeficiency viruses
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- PMID: 1383411
- DOI: 10.1099/0022-1317-73-9-2445
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Comparative Study
Highly conserved epitope domain in major core protein p24 is structurally similar among human, simian and feline immunodeficiency viruses
J Gen Virol.
1992 Sep.
Abstract
Linear B cell epitopes were mapped on the major core protein p24 of human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIVAGM) and feline immunodeficiency virus (FIV) using a fusion protein-based method and murine monoclonal antibodies reactive against the p24 antigens expressed on the surface of HIV-1- and FIV-infected cells. The results suggest that the sites identified here are encoded at similar positions in the three virus genomes and consist of highly conserved epitopes, which could exhibit immunodominance.
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