Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1959 Sep;14(3):327-33.
doi: 10.1111/j.1476-5381.1959.tb00252.x.

The fate of oxytocin in male and female rats

M GINSBURG, M W SMITH

The fate of oxytocin in male and female rats

M GINSBURG et al. Br J Pharmacol Chemother. 1959 Sep.

Abstract

A method for quantitative extraction of oxytocin from blood is described. The disappearance of injected oxytocin from the circulation in rats was shown to depend upon its uptake in the kidneys and in organs of the splanchnic vascular area. In lactating rats there was uptake by an additional organ or tissue, probably the mammary gland. In animals without kidneys or lactating mammary glands and with no circulation in the splanchnic area oxytocin was distributed into a volume greater than the extracellular fluid volume, and after equilibration the concentration in plasma did not change significantly. During severe haemorrhage increased amounts of antidiuretic activity were detected in blood when there was no significant increase in oxytocic activity.

PubMed Disclaimer

References

    1. Proc Soc Exp Biol Med. 1954 Nov;87(2):463-5 - PubMed
    1. Proc Soc Exp Biol Med. 1954 Nov;87(2):352-5 - PubMed
    1. J Endocrinol. 1953 Jul;9(3):267-73 - PubMed
    1. J Physiol. 1936 Jul 21;87(2):144-57 - PubMed
    1. Endocrinology. 1954 Nov;55(5):699-700 - PubMed

LinkOut - more resources