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. 1959 Sep;14(3):358-63.
doi: 10.1111/j.1476-5381.1959.tb00257.x.

The pharmacology of the ethanesulphonate anion

P J GOODFORD, H R ING

The pharmacology of the ethanesulphonate anion

P J GOODFORD et al. Br J Pharmacol Chemother. 1959 Sep.

Abstract

A method of preparing analytically pure sodium ethanesulphonate, C(2)H(5)SO(3)Na.H(2)O, in quantity is described. Physiological saline solutions were prepared in which a proportion of the sodium chloride normally present was replaced by an equimolar concentration of sodium ethanesulphonate. The effects of partial or total replacement of sodium chloride were examined upon a series of isolated organs, and the guinea-pig ileum preparation was found to be particularly sensitive to the change. Evidence is presented that these low-chloride solutions depolarized the cell membrane of smooth muscle, and that this effect might have been due to an alteration of the chloride ion potential.

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