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. 1962 Feb;18(1):101-8.
doi: 10.1111/j.1476-5381.1962.tb01154.x.

Antihistamine activity in extracts of horse eosinophils

R K ARCHER, W FELDBERG, B A KOVACS

Antihistamine activity in extracts of horse eosinophils

R K ARCHER et al. Br J Pharmacol Chemother. 1962 Feb.

Abstract

Suspensions of horse eosinophils or the watery extracts of such suspensions were injected intraperitoneally into guinea-pigs. The eosinophils were obtained from 9 healthy cross-bred ponies. The number of eosinophils used for each injection varied between 20 and 300 millions. The guinea-pigs were exposed to a 0.6% histamine aerosol 1 to 8 hr later. The eosinophils of 5 ponies produced protection against the aerosol, the eosinophils of the other 4 ponies did not. Protection when produced did not last as long as 23 hr. The active principle in the watery extracts was stable, after freeze drying, for at least a few weeks.

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