Review
doi: 10.1016/0959-4388(92)90169-l.
The emerging neuropoietic cytokine family: first CDF/LIF, CNTF and IL-6; next ONC, MGF, GCSF?
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- PMID: 1386269
- DOI: 10.1016/0959-4388(92)90169-l
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Review
The emerging neuropoietic cytokine family: first CDF/LIF, CNTF and IL-6; next ONC, MGF, GCSF?
Curr Opin Neurobiol.
1992 Feb.
Abstract
CDF/LIF is a polyfunctional cytokine that shares a remarkable overlap with ciliary neurotrophic factor in its actions on neurons, and with interleukin-6 in its actions on other tissues. Moreover, the receptors for this cytokine, as well as those for ciliary neurotrophic factor, share homology with the subunits of the interleukin-6 receptor. The predicted structural similarity of these proteins with oncostatin M, myelomonocytic growth factor and granulocyte colony-stimulating factor, as well as at least a partial overlap in biological activities, is now prompting further examination of their roles in neuronal gene expression.
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