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. 1992 Mar 17;213(1):155-8.
doi: 10.1016/0014-2999(92)90248-3.

Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons

H U Zeilhofer  1 , D Swandulla, G Geisslinger, K Brune
Affiliations

Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons

H U Zeilhofer et al. Eur J Pharmacol. .

Abstract

The effects of R- and S-ketamine on N-methyl-D-aspartate receptor-activated cation currents (NMDA receptor currents) of voltage-clamped cultured rat hippocampal neurons were investigated using the whole-cell patch-clamp technique. Both enantiomers exhibited a voltage- and use-dependent blockade of NMDA receptor currents, with the S-enantiomer being about twice as potent as the R-enantiomer. Calculated relative forward and backward rates suggest that conformational differences influence the dissociation from the binding site more than the association with it.

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