Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1992 May:8 Suppl 1:83-7.
doi: 10.1007/BF00145356.

Fibrinogen/fibrin in atherogenesis

E B Smith  1 , W D Thompson, L Crosbie, C M Stirk
Affiliations
Review

Fibrinogen/fibrin in atherogenesis

E B Smith et al. Eur J Epidemiol. 1992 May.

Abstract

Fibrin is a major component of many atherosclerotic plaques. Within the intima there is continuous formation of fibrin, and continuous fibrinolysis. In aortic lesions, a lipoprotein bound to fibrin can be released by incubation with plasmin. Most of this lipoprotein is accounted for by Lp(a). The atherogenicity of Lp(a) may be more associated with lipid deposition than with inhibition of fibrinolysis. Fibrin degradation products may be chemotactic to monocyte-macrophages and stimulate smooth muscle cell proliferation.

PubMed Disclaimer

References

    1. Arteriosclerosis. 1990 Mar-Apr;10(2):263-75 - PubMed
    1. Blood Coagul Fibrinolysis. 1990 Oct;1(4-5):517-20 - PubMed
    1. Blood Coagul Fibrinolysis. 1990 Oct;1(4-5):489-93 - PubMed
    1. Lancet. 1986 Sep 6;2(8506):533-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 May;84(10):3224-8 - PubMed

Publication types

LinkOut - more resources