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. 1961 Dec 1;114(6):857-74.
doi: 10.1084/jem.114.6.857.

Effects of bacterial endotoxin on rabbit platelets. I. Platelet aggregation and release of platelet factors in vitro

R M DES PREZ, H I HOROWITZ, E W HOOK

Effects of bacterial endotoxin on rabbit platelets. I. Platelet aggregation and release of platelet factors in vitro

R M DES PREZ et al. J Exp Med. .

Abstract

Incubation of platelet-rich rabbit plasma with E. coli endotoxin at 37 degrees C results in platelet aggregation and transfer of platelet 5-hydroxytryptamine to plasma. Release of 5HT is influenced by dose of endotoxin, type of anticoagulant, and temperature of incubation. A heat-labile plasma factor is necessary for the platelet-endotoxin interaction. Additional studies have shown that incubation of endotoxin with platelet-rich rabbit plasma also results in release of platelet phospholipid and bactericidins active against B. subtilis.

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