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. 1962 Jan;5(1):104-9.

Antibodies with differing molecular sizes in mice

J L FAHEY, J H HUMPHREY

Antibodies with differing molecular sizes in mice

J L FAHEY et al. Immunology. 1962 Jan.

Abstract

The antibody responses of C3H mice to haemocyanin, pneumococcal polysaccharide (SSS III) and sheep erythrocytes were studied after a single intravenous administration. Serum antibody against each antigen was present on the fifth, but not on the third day.

Antibodies against haemocyanin and against SSS III migrated electrophoretically as γ globulins and had the ultracentrifugal sedimentation properties of 6.5S globulins. Sheep erythrocyte haemolysins were largely γ macroglobulins which sedimented in the ultracentrifuge in the manner of 18S globulins. A small proportion of haemolysin activity was found among the 6.5S γ globulins.

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