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. 1962 Feb;83(2):297-300.
doi: 10.1128/jb.83.2.297-300.1962.

Properties of two regulating genes for alkaline phosphatase

Properties of two regulating genes for alkaline phosphatase

A GAREN et al. J Bacteriol. 1962 Feb.

Abstract

Garen, A. (University of Pennsylvania, Philadelphia) and H. Echols. Properties of two regulating genes for alkaline phosphatase. J. Bacteriol. 83:297-300. 1962.-A constitutive mutation in one of the two regulating genes for alkaline phosphatase has two effects on the synthesis of the enzyme: repression of synthesis is blocked, and the cell's capacity to produce the enzyme is reduced. The behavior of this type of mutation has been studied in heterozygotes. The results suggest that the product of this regulating gene functions as an inducer as well as a repressor.

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References

    1. J Mol Biol. 1961 Aug;3:425-38 - PubMed
    1. Brookhaven Symp Biol. 1959 Nov;12:76-85 - PubMed
    1. Biochim Biophys Acta. 1960 Mar 11;38:460-9 - PubMed

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