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. 1961 Dec 1;114(6):987-96.
doi: 10.1084/jem.114.6.987.

The vacuolating virus of monkeys. II. Virus morphology and intranuclear distribution with some histochemical observations

W H GAYLORD Jr, G D HSIUNG

The vacuolating virus of monkeys. II. Virus morphology and intranuclear distribution with some histochemical observations

W H GAYLORD Jr et al. J Exp Med. .

Abstract

Cells infected with the vacuolating virus, SV(40), respond by swelling to several times their normal volume. Within enlarged nuclei, virus-containing inclusions appear which are acidophilic and Feulgen-positive. The formation of nuclear inclusions is followed by the appearance of cytoplasmic vacuoles and then shrinkage of the cell. Inclusions were found to exhibit unique double staining when a light-green counterstain was used in the Feulgen reaction. The virus is of low electron density, round, and 300 A in diameter. It occurs in large numbers, singly and in short chains, and it appears to multiply at the expense of chromatin.

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