Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992;111(5):265-7.
doi: 10.1007/BF00571521.

Types I and III procollagen extension peptides in serum respond to fracture in humans

S Joerring  1 , L T Jensen, G R Andersen, J S Johansen
Affiliations

Types I and III procollagen extension peptides in serum respond to fracture in humans

S Joerring et al. Arch Orthop Trauma Surg. 1992.

Abstract

Markers of types I and III collagen turnover were measured in serial blood samples in 16 patients with a Colles' fracture. The collagen markers were the carboxy-terminal extension peptide of type I procollagen (PICP) and the amino-terminal extension peptide of type III procollagen (PIIINP). Significant increases were found of PIIINP within 1 week and of PICP within 2 weeks. This sequential appearance of PIIINP and PICP was found to be in agreement with the appearance of types III and I collagen during early fracture healing as demonstrated in previous animal experimental studies. PICP had levelled off after 9 months, whereas PIIINP remained elevated. Osteocalcin, a serum marker of osteoblast activity, increased within 1 week and levelled off after 9 months. Correlations between the change in osteocalcin and those in PICP and PIIINP, respectively, were weak. These new biochemical markers may prove relevant as non-invasive markers of normal and pathological fracture healing in humans.

PubMed Disclaimer

References

    1. J Bone Miner Res. 1987 Oct;2(5):427-36 - PubMed
    1. Acta Chir Scand. 1978;144(4):205-11 - PubMed
    1. J Bone Joint Surg Am. 1990 Oct;72(9):1374-8 - PubMed
    1. J Bone Joint Surg Br. 1971 Aug;53(3):519-31 - PubMed
    1. Surgery. 1990 Apr;107(4):381-8 - PubMed

Publication types