doi: 10.1084/jem.114.5.729.
Studies on the pathogenesis of fever. VIII. Further observations on the role of endogenous pyrogen in endotoxin fever
- PMID: 13898672
- PMCID: PMC2180372
- DOI: 10.1084/jem.114.5.729
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Studies on the pathogenesis of fever. VIII. Further observations on the role of endogenous pyrogen in endotoxin fever
J Exp Med.
.
Abstract
Rabbits made granulocytopenic with nitrogen mustard have been shown to generate serum endogenous pyrogen when given a fever-producing dose of bacterial endotoxin. This finding is in accord with the hypothesis that endogenous pyrogen plays a central role in the pathogenesis of endotoxin fever. The fact that leucopenic animals produce less serum-endogenous pyrogen than normal animals given the same dose of endotoxin has also been confirmed and suggests that polymorphonuclear leucocytes constitute a major source of the endogenous pyrogen which is demonstrable in the circulation during endotoxin fever.
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