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. 1977 Jan;59(1):17-23.
doi: 10.1111/j.1476-5381.1977.tb06971.x.

The beta-adrenoceptor of the human lymphocyte and human lung parenchyma

M E Conolly, J K Greenacre

The beta-adrenoceptor of the human lymphocyte and human lung parenchyma

M E Conolly et al. Br J Pharmacol. 1977 Jan.

Abstract

1 The response of the beta-adrenoceptors of human lymphocytes to selective agonists and antagonists has been studied quantitatively by measuring changes in cyclic adenosine-3',5'-monophosphate (cyclic AMP) levels. 2 The receptor was activated by isoprenaline and by salbutamol, and blocked by propranolol but not by practolol. A similar pattern of response was obtained with fragments of human lung tissue. 3 The mean value for pA2 for propranolol was 8.34 and for practolol was 3.95. 4 These findings indicate that the lymphocyte beta-adrenoceptor is a beta2-receptor and support the solidity of using lymphocytes to study beta-adrenoceptor function in bronchial asthma. It may also be of use in the evaluation of selective beta2-blocking drugs in man.

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References

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