Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Jan;59(1):17-23.
doi: 10.1111/j.1476-5381.1977.tb06971.x.

The beta-adrenoceptor of the human lymphocyte and human lung parenchyma

M E Conolly, J K Greenacre

The beta-adrenoceptor of the human lymphocyte and human lung parenchyma

M E Conolly et al. Br J Pharmacol. 1977 Jan.

Abstract

1 The response of the beta-adrenoceptors of human lymphocytes to selective agonists and antagonists has been studied quantitatively by measuring changes in cyclic adenosine-3',5'-monophosphate (cyclic AMP) levels. 2 The receptor was activated by isoprenaline and by salbutamol, and blocked by propranolol but not by practolol. A similar pattern of response was obtained with fragments of human lung tissue. 3 The mean value for pA2 for propranolol was 8.34 and for practolol was 3.95. 4 These findings indicate that the lymphocyte beta-adrenoceptor is a beta2-receptor and support the solidity of using lymphocytes to study beta-adrenoceptor function in bronchial asthma. It may also be of use in the evaluation of selective beta2-blocking drugs in man.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Br J Pharmacol. 1971 Feb;41(2):426P-427P - PubMed
    1. J Pharm Pharmacol. 1970 Mar;22(3):180-8 - PubMed
    1. J Clin Invest. 1973 Jan;52(1):48-59 - PubMed
    1. J Clin Endocrinol Metab. 1973 Apr;36(4):627-33 - PubMed
    1. J Allergy. 1967 Dec;40(6):337-48 - PubMed

LinkOut - more resources