Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Sep;65(3):135-7.
doi: 10.1007/BF01695813.

Platelet heterogeneity based on lactic dehydrogenase activity

P De Sole  1 , B Zappacosta
Affiliations

Platelet heterogeneity based on lactic dehydrogenase activity

P De Sole et al. Ann Hematol. 1992 Sep.

Abstract

Mean lactic dehydrogenase (LDH) activity of human platelets is about 5 nU/platelet; expressed on a cell volume basis, it is 0.5 nU/fl. Platelet separation by means of centrifugation on a Percoll discontinuous gradient gives different subpopulations with a clear-cut change of LDH at a mean platelet volume (MPV) of about 6 fl. The LDH content of platelets with a MPV > 6 fl is constant (about 0.5 nU/fl), while that of small platelets (3 < MPV < 6 fl) is inversely correlated with the MPV and reaches a value of 1.5-2.0 nU/fl. Because small platelets are granule-depleted, we suggest that platelet LDH activity be considered as an in vivo activation index.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. J Am Geriatr Soc. 1987 Oct;35(10):947-56 - PubMed
    1. J Clin Invest. 1972 May;51(5):1235-43 - PubMed
    1. Am J Hematol. 1984;17(4):373-82 - PubMed
    1. Br J Haematol. 1976 Dec;34(4):639-53 - PubMed
    1. Blood. 1977 Jan;49(1):71-87 - PubMed

Substances

LinkOut - more resources