[Interactions of mast cells and leukocytes in increased vascular permeability in the focus of inflammation]

Abstract

On the model of acute infectious peritonitis in rats it is shown that the mast cell depletion affected the inflammatory focus vascular permeability mainly in the immediate phase of its increase. Leukopenia inhibited the permeability both in the immediate and delayed phases. The combined depletion of mast cells and leukocytes not only inhibited the degree of vascular permeability increase but strongly affected its kinetics during exudative phase of peritonitis. The results indicate that in the natural conditions of inflammation the mast cell-leukocyte interaction in the vascular permeability increase takes place.