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Review
. 1992 Sep;18(3):227-36.
doi: 10.1016/0169-6009(92)90809-r.

On the rat model of human osteopenias and osteoporoses

H M Frost  1 , W S Jee
Collaborators, Affiliations
Review

On the rat model of human osteopenias and osteoporoses

H M Frost et al. Bone Miner. 1992 Sep.

Abstract

The idea that rats cannot model human osteopenias errs. The same mechanisms control gains in bone mass (longitudinal bone growth and modeling drifts) and losses (BMU-based remodeling), in young and aged rats and humans. Furthermore, they respond similarly in rats and man to mechanical influences, hormones, drugs and other agents.

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