Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1963 Jun 1;117(6):951-64.
doi: 10.1084/jem.117.6.951.

Properties of guinea pig 7S antibodies. II. Identification of antibodies involved in passive cutaneous and systemic anaphylaxis

Z OVARY, B BENACERRAF, K J BLOCH

Properties of guinea pig 7S antibodies. II. Identification of antibodies involved in passive cutaneous and systemic anaphylaxis

Z OVARY et al. J Exp Med. .

Abstract

Guinea pig 7Sgamma(1) antibodies were demonstrated to mediate passive systemic or cutaneous anaphylaxis; guinea pig 7Sgamma(2) antibodies were unable to mediate these reactions. Gamma-2 antibodies specifically inhibited passive cutaneous anaphylactic reactions provoked by gamma-1 antibodies by competing for antigen. However, gamma-2 antibodies were unable to inhibit passive cutaneous sensitization of guinea pigs by a heterologous antibody system. Guinea pig 7Sgamma(2) antibodies appear to lack receptors for fixation to guinea pig tissues and do not compete with sensitizing antibody for receptor sites.

PubMed Disclaimer

References

    1. J Exp Med. 1963 Jun 1;117:965-81 - PubMed
    1. J Immunol. 1949 Aug;62(4):517-22 - PubMed
    1. J Immunol. 1953 Jul;71(1):6-11 - PubMed
    1. J Exp Med. 1960 Apr 1;111:465-83 - PubMed
    1. J Exp Med. 1963 Jun 1;117:937-49 - PubMed