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Case Reports
. 1992 Sep;8(6):354-6.
doi: 10.1007/BF00296569.

Acute severe combined demyelination

R Amit  1 , B Glick, Y Itzchak, Y Dgani, S Meyeir
Affiliations
Case Reports

Acute severe combined demyelination

R Amit et al. Childs Nerv Syst. 1992 Sep.

Abstract

We present a second case in which Guillain-Barré syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) appeared simultaneously, both in acute and fulminant form. The patient, a 10-year-old girl, presented with acute onset of coma and flaccid, are-flexic quadriparesis. The elevated CSF protein levels and delayed F waves fulfilled the criteria of GBS and an MRI study revealed extensive multifocal demyelination compatible with a diagnosis of ADEM. Prompt clinical response followed by complete recovery was achieved by treatment with corticosteroids. It is suggested that acute severe combined demyelination might constitute a separate entity in which the demyelinating process, involving simultaneously the central and the peripheral nervous systems, indicates immune response against a component of the myelin of one system carrying cross-antigenicity with the other.

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References

    1. Brain. 1966 Jun;89(2):205-22 - PubMed
    1. J Comput Assist Tomogr. 1986 Sep-Oct;10(5):798-801 - PubMed
    1. Dev Med Child Neurol. 1968 Aug;10(4):485-90 - PubMed
    1. Ann Neurol. 1981;9 Suppl:56-64 - PubMed
    1. Neurology. 1987 Aug;37(8):1287-90 - PubMed

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