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. 1963 Jun;20(3):563-8.
doi: 10.1111/j.1476-5381.1963.tb01493.x.

Some neurochemical aspects of the depressant action of gamma-butyrolactone on the central nervous system

N J GIARMAN, K F SCHMIDT

Some neurochemical aspects of the depressant action of gamma-butyrolactone on the central nervous system

N J GIARMAN et al. Br J Pharmacol Chemother. 1963 Jun.

Abstract

gamma-Butyrolactone, a depressant drug of the central nervous system, has been investigated for its ability to alter brain levels of 5-hydroxytryptamine, gamma-aminobutyric acid and acetylcholine in mice and rats; of these three compounds, only acetylcholine was changed in amount. Levels of acetylcholine in the cerebral cortex were increased by gamma-butyrolactone with a time-course which closely followed the depressed state of the animal. Indirect evidence has been presented to show that in the mid-brain and brain stem the change in acetylcholine level induced by gamma-butyrolactone is sharply localized in an area of the mesencephalon that contains the corpora quadrigemina.

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