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. 1963 Jul 12;141(3576):160-1.
doi: 10.1126/science.141.3576.160-a.

Glycogen deposition in the liver induced by cortisone: dependence on enzyme synthesis

O GREENGARD, G WEBER, R L SINGHAL

Glycogen deposition in the liver induced by cortisone: dependence on enzyme synthesis

O GREENGARD et al. Science. .

Abstract

The deposition of liver glycogen in starved rats given a single dose of cortisone is inhibited by puromycin and actinomycin. The former agent interferes with induced enzyme formation in general, and the latter with the cortisone-induced rise in liver enzyme levels. The results suggest that the regulatory eJffect of cortisone on carbohydrate metabolism may be brought about -by its action on the cellular concentration of certain enzyme proteins.

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