Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1963 Jun 1;117(6):1019-34.
doi: 10.1084/jem.117.6.1019.

Experimental glomerulonephritis. II. Immunologic events in the pathogenesis of nephrotoxic serum nephritis in the rat

D K HAMMER, F J DIXON

Experimental glomerulonephritis. II. Immunologic events in the pathogenesis of nephrotoxic serum nephritis in the rat

D K HAMMER et al. J Exp Med. .

Abstract

The primary phase of nephrotoxic serum nephritis produced by rabbit nephrotoxic serum appears to be dependent to a great extent, but not completely, upon the participation of serum complement. On the other hand, duck nephrotoxic serum produces its primary renal injury without detectable utilization of or dependence upon serum complement. The secondary phase of nephrotoxic serum nephritis appears to be largely or entirely dependent upon the host's antibody response to the heterologous gamma globulin fixed in the glomeruli. No evidence could be obtained for the existence of an autoimmune antikidney response by the host in this experimental model.

PubMed Disclaimer

References

    1. J Exp Med. 1958 Jul 1;108(1):139-57 - PubMed
    1. AMA Arch Pathol. 1957 Aug;64(2):192-204 - PubMed
    1. Proc Soc Exp Biol Med. 1954 Apr;85(4):593-6 - PubMed
    1. Am J Syph Gonorrhea Vener Dis. 1952 Mar;36(2):140-53 - PubMed
    1. Proc Soc Exp Biol Med. 1961 Jan;106:13-6 - PubMed