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. 1963 Apr 13;88(15):797-802.

A psychiatric and psychological study of amitriptyline (Elavil) as an antidepressant

J INGLIS, R P JONES, R B SLOANE

A psychiatric and psychological study of amitriptyline (Elavil) as an antidepressant

J INGLIS et al. Can Med Assoc J. .

Abstract

The antidepressant effects of amitriptyline (Elavil) were investigated by means of psychiatric assessment and psychological testing of 20 depressed patients who were compared, before and after treatment, with a placebo-treated control group of 14 similar patients. After three weeks on doses of 150 mg. per day, 13 out of 20 of the actively treated group were rated as improved, compared with only three out of 11 of the control group (p < .05). Clinical improvement was associated with changes on some objective tests. No persistent adverse side effects were observed. It was concluded that amitriptyline is an effective antidepressant.

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