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. 1963 Jan 11;139(3550):110-1.
doi: 10.1126/science.139.3550.110.

Metabolic deficiencies in protozoa induced by thalidomide

O FRANK, H BAKER, H ZIFFER, S AARONSON, S H HUTNER, C M LEEVY

Metabolic deficiencies in protozoa induced by thalidomide

O FRANK et al. Science. .

Abstract

Thalidomide inhibits growth of some protozoa. This inhibition was counteracted by nicotinic acid, nicotinamide, nicotinamide adenine dinucleotide, and vitamin K(1). The mechanism of toxicity may be an interference of cellular oxidation. A protozoan test system is useful for studying the potential "side actions" of drugs in higher animals and man.

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