Recognition of the species of origin of cells in culture by mixed agglutination. III. Identification of the cells of different primates

Abstract

Cultured tissue cells from different primates may be identified by means of the mixed agglutination reaction using suitable antisera prepared in rabbits and in Old World monkeys. In this way it has been possible to differentiate human, Rhesus, Patas and Vervet monkey cells. Several cell lines thought to be derived from Rhesus monkey tissue have been shown to have human species antigens, but not Rhesus monkey antigens, suggesting that the original Rhesus monkey cells have been replaced by human cells. Antigens similar to the human A and B blood group antigens have been identified on Rhesus monkey tissue cells ex vivo, and these have been shown to persist in long-term cultures of Rhesus monkey cells.