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Comparative Study
. 1992 Sep-Oct;33(5):932-5.
doi: 10.1111/j.1528-1157.1992.tb02203.x.

Total cholesterol, high-density lipoprotein cholesterol, and triglycerides in children receiving antiepileptic drugs

E Franzoni  1 , M Govoni, S D'Addato, S Gualandi, Z Sangiorgi, G C Descovich, G P Salvioli
Affiliations
Comparative Study

Total cholesterol, high-density lipoprotein cholesterol, and triglycerides in children receiving antiepileptic drugs

E Franzoni et al. Epilepsia. 1992 Sep-Oct.

Abstract

The influence of antiepileptic drug (AED) therapy on total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and triglycerides was studied in 208 epileptic children compared with 175 normal children. A significant increase in TC plasma levels was observed with carbamazepine (CBZ), phenobarbital (PB), and phenytoin (PHT). The patients receiving valproate (VPA) showed levels very similar to those of the control population. The results may be explainable by the different biotransformation pathway of these drugs. HDL cholesterol and triglycerides were not altered by any of the AEDs. We recommend monitoring TC level in patients receiving CBZ, PB, and PHT and prescription of diet treatment, at least during the time of AED treatment.

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