Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1962 Dec;19(3):544-51.
doi: 10.1111/j.1476-5381.1962.tb01460.x.

Potentiation of the response to histamine by picolylamines

H BLASCHKO, S KURZEPA

Potentiation of the response to histamine by picolylamines

H BLASCHKO et al. Br J Pharmacol Chemother. 1962 Dec.

Abstract

The response of the isolated ileum of the guinea-pig to histamine is potentiated in the presence of 2-, 3- or 4-picolylamine. These compounds have been found to inhibit the histaminase and/or "diamine oxidase" of pig kidney. The three corresponding picolylmethylamines did not potentiate the response of the ileum to histamine; they were without significant affinity for the pig kidney oxidase. It is suggested that the potentiating action of the three primary amines is due to their inhibitory action on histaminase. The responses of the ileum to acetylcholine and 5-hydroxytryptamine were not potentiated.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. J Physiol. 1954 Jan;123(1):32-54 - PubMed
    1. Adv Comp Physiol Biochem. 1962;1:67-116 - PubMed
    1. Br J Pharmacol Chemother. 1959 Sep;14:364-7 - PubMed

LinkOut - more resources