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Comparative Study
. 1992 Oct 26;311(3):305-10.
doi: 10.1016/0014-5793(92)81126-7.

Genomic organization and full-length cDNA sequence of human collagen X

E Reichenberger  1 , F Beier, P LuValle, B R Olsen, K von der Mark, W M Bertling
Affiliations
Free article
Comparative Study

Genomic organization and full-length cDNA sequence of human collagen X

E Reichenberger et al. FEBS Lett. .
Free article

Abstract

We have determined the full-length cDNA sequence of the human alpha 1(X) collagen gene by sequence analysis of a genomic clone ERG [(1991) Dev. Biol. 148, 562-572], and of cDNA fragments generated from a reverse transcribed as alpha 1(X) mRNA by PCR. We defined the promoter region, the transcription initiation site and the full-length 5'-untranslated region. We also report the exon/intron boundaries of the transcript and the complete 3'-untranslated region as well as a 3'-flanking sequence containing two additional polyadenylation signals. The promoter region is homologous to chicken and mouse type X promoters within several highly conserved regions. The genomic organization shows high homologies to chicken and mouse.

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