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. 1977 Jan;40(3):299-306.
doi: 10.1111/j.1469-1809.1977.tb00194.x.

Paternal age effect in Down's syndrome

J Stene, G Fischer, E Stene, M Mikkelsen, E Petersen

Paternal age effect in Down's syndrome

J Stene et al. Ann Hum Genet. 1977 Jan.

Abstract

Increasing incidence of Down's syndrome with advancing paternal age for given maternal age has been demonstrated. Comparisons are made between an almost complete Down's syndrome sample from the Copenhagen Metropolitan Area and a randomly selected sample of births from the same area and the same time period. Men above 55 years have a significantly increased risk of getting children with Down's syndrome.

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