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. 1992 Sep;77(1):147-9.

Neutrophil priming by hepatocyte growth factor, a novel cytokine

W Jiang  1 , M C Puntis, T Nakamura, M B Hallett
Affiliations

Neutrophil priming by hepatocyte growth factor, a novel cytokine

W Jiang et al. Immunology. 1992 Sep.

Abstract

We demonstrate here that the recently defined cytokine hepatocyte growth factor (HGF) 'primes' human neutrophils. Recombinant human HGF over the concentration range 0.1-20 ng/ml increased the neutrophil response to f-met-leu-phe by up to 200%, and required only a short preincubation, 10 min producing the maximum effect. Priming was independent of changes in cytosolic-free calcium homeostasis. We conclude that HGF may be a physiologically important cytokine with 'priming' activity for neutrophils.

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References

    1. J Clin Invest. 1988 Feb;81(2):414-9 - PubMed
    1. Biochem Biophys Res Commun. 1990 Dec 31;173(3):1179-85 - PubMed
    1. J Leukoc Biol. 1991 Dec;50(6):547-53 - PubMed
    1. Biochem J. 1990 Jul 15;269(2):431-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7001-5 - PubMed

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