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Clinical Trial
. 1992 Oct;60(10):4430-2.
doi: 10.1128/iai.60.10.4430-4432.1992.

Safety and immunogenicity in North Americans of a single dose of live oral cholera vaccine CVD 103-HgR: results of a randomized, placebo-controlled, double-blind crossover trial

K L Kotloff  1 , S S Wasserman, S O'Donnell, G A Losonsky, S J Cryz, M M Levine
Affiliations
Clinical Trial

Safety and immunogenicity in North Americans of a single dose of live oral cholera vaccine CVD 103-HgR: results of a randomized, placebo-controlled, double-blind crossover trial

K L Kotloff et al. Infect Immun. 1992 Oct.

Abstract

We conducted a double-blind, placebo-controlled, randomized crossover study to evaluate the safety and immunogenicity of a single 5 x 10(8)-CFU dose of live oral recombinant cholera vaccine CVD 103-HgR in 94 North American adults. The vaccine was well tolerated without associated adverse reactions. Despite minimal fecal excretion of vaccine, 97% of subjects exhibited serum vibriocidal antibody and 72% had antitoxin responses.

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