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. 1962 Oct 19;138(3538):440-2.
doi: 10.1126/science.138.3538.440.

Localizing tritiated norepinephrine in sympathetic axons by electron microscopic autoradiography

D E WOLFE, L T POTTER, K C RICHARDSON, J AXELROD

Localizing tritiated norepinephrine in sympathetic axons by electron microscopic autoradiography

D E WOLFE et al. Science. .

Abstract

Following intravenous infusion of tritiated norepinephrine, rat pineals were prepared for combined autoradiography and electron microscopy. Concentrations of photographic grains were observed only over regions of preterminal autonomic axons containing granulated vesicles, thereby directly demonstrating uptake of norepinephrine into these axons and strongly suggesting that their granulated vesicles contain norepinephrine.

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