Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1992 Sep;45(9):766-9.
doi: 10.1136/jcp.45.9.766.

Increased interleukin 6 concentrations in the absence and presence of HIV-1 infection in haemophilia

R Madhok  1 , A Cruickshank, A J Gracie, A Shenkin, G D Lowe
Affiliations
Comparative Study

Increased interleukin 6 concentrations in the absence and presence of HIV-1 infection in haemophilia

R Madhok et al. J Clin Pathol. 1992 Sep.

Abstract

Aims: To measure IL-6 concentrations in asymptomatic HIV-1 antibody positive and negative haemophilic patients and to correlate these with IgG concentrations and CD4 positive cell numbers.

Methods: IL-6 concentrations were measured by bioassay in stored serum from a prospective cohort of haemophilic patients in whom immunoglobulins and T cell subsets had been determined. Values of IL-6 and immunoglobulins were also correlated with severity of liver disease.

Results: IL-6 concentrations were raised in haemophilic patients independent of HIV-1 antibody status. In HIV-1 antibody positive patients there was no correlation between IL-6 concentrations and CD4 positive cell numbers, but there was a correlation with IgG (r = 0.4; p = 0.05). In HIV-1 antibody negative patients there were no significant correlations.

Conclusions: Haemophilic patients have increased IL-6 concentrations; in HIV-1 positive patients this is independent of the decline in CD4 cell count. The raised concentrations do not correlate with the clinical severity of liver disease.

PubMed Disclaimer

References

    1. J Immunol. 1990 Feb 15;144(4):1317-22 - PubMed
    1. J Immunol Methods. 1983 Dec 16;65(1-2):55-63 - PubMed
    1. Clin Exp Immunol. 1986 Feb;63(2):354-8 - PubMed
    1. Science. 1987 May 22;236(4804):944-7 - PubMed
    1. J Immunol. 1988 May 1;140(9):3040-4 - PubMed

Publication types