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. 1963 Jul;16(4):362-6.
doi: 10.1136/jcp.16.4.362.

SYNERGISM BETWEEN SULPHONAMIDE DRUGS AND ANTIBIOTICS OF THE POLYMYXIN GROUP AGAINST PROTEUS SP. IN VITRO

F E RUSSELL

SYNERGISM BETWEEN SULPHONAMIDE DRUGS AND ANTIBIOTICS OF THE POLYMYXIN GROUP AGAINST PROTEUS SP. IN VITRO

F E RUSSELL. J Clin Pathol. 1963 Jul.

Abstract

Interesting synergism in vitro between a recently introduced antibiotic, colistin methane sulphonate, and sulphonamide drugs is described. The observations were extended to polymyxin B sulphate and sulphonamides with essentially similar results. The combinations are bactericidal at therapeutic levels, the ratio of drugs to one another is not critical, and the effect is present over a fairly wide pH range.

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References

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    1. Br Med J. 1962 Jul 21;2(5298):161-3 - PubMed
    1. Lancet. 1962 Oct 13;2(7259):737-9 - PubMed
    1. Antibiot Annu. 1958-1959;6:836-9 - PubMed

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